The galactose moiety of Lac/LacNAc is most deeply buried in the binding site (Fig. 2); 166 Å2 of its total 230-Å2 surface area is buried by the protein. Its C-4 ...

May 22, 1998 · We report here the x-ray crystal structure of the human galectin-3 CRD, in complex with lactose and N-acetyllactosamine, at 2.1-A resolution.

Nov 23, 2011 · High-resolution structural information greatly aids in this respect. Here we report a study that combines X-ray crystallography, NMR ...

The carbohydrate binding site is similar in galectin-1 and galectin-2, consistent with the demonstrated ability of galectins-1 and -3 to bind longer oligo-.

Dec 3, 2019 · Galectins (formerly known as “S-type lectins”) are a subfamily of soluble proteins that typically bind β-galactoside carbohydrates with high ...

Several important advances in the structure determination of animal lectins were made in the past year. The X-ray crystal structures of trimeric fragments ...

Galectins constitute a family of endogenous galactoside-binding lectins with conserved features in the binding site. The members of this lectin category are ...

The results of the X-ray and modeling studies show that the disaccharides with an α-1,3 linkage prefer to have the nonreducing end at the primary binding site, ...

Nov 23, 2011 · Here we report the high- to ultra-high-resolution crystal structures of the carbohydrate recognition domain of galectin-3 (Gal3C) in the ligand- ...

Jul 24, 2009 · Although animal lectins usually show a high degree of specificity for glycan structures, their single-site binding affinities are typically low.